Development of a Reference Material for Characterizing Adenovirus Vectors

by Beth Hutchins, PhD
Volume 1, Issue 1 (March 2002)

The development of reference testing reagents has been used successfully in the past to standardize measurements among laboratories, particularly for biological products such as recombinant cytokines. This approach was recommended by many parties with a stake in adenovirus vector delivery in order to address the fact that particle units and infectious units are not standardized in the field. This has made interpretation of preclinical and clinical data, as it relates to the amount of adenovirus vector administered, difficult to compare across the field. An Adenovirus Reference Material is being developed to define the particle unit and infectious unit for adenovirus gene vectors, and create a commonality for comparisons, especially for data related to vector safety...

Citation:
Hutchins B. Development of a Reference Material for Characterizing Adenovirus Vectors. BioProcess J, 2002; 1(1): 25-29.