Connection Technology Advances Closed System Processing: Single-Use Connectors Create Improved Flexibility and Reliability, and Drive Cost Savings for Biopharmaceutical Manufacturers

by John Boehm
Volume 13, Issue 1 (Spring 2014)

The global demand for new biologics and vaccines, combined with the growing emergence of biosimiliars, is challenging drugmakers to re-evaluate their processes and seek ways to make them more flexible, reliable, and cost-effective. Increasingly, manufacturers are turning to closed, single-use processing systems to meet aggressive campaign turnaround times, reduce risks, and control costs. Innovative single-use technologies provide biopharmaceutical manufacturers greater flexibility for replacing traditional stainless piping, valves, equipment, or even entire process suites with polymer-based solutions. The benefits of converting to pre-sterilized, single-use systems have been documented in numerous articles and case studies, and these benefits would be lost if manufacturers could not safely and securely connect a variety of systems and components together to create a complete aseptic process. Connectology may appear to be a small part of an overall system design; however, connection and disconnection of tubing for process fluid transfer is a critical aspect of single-use processing. Manufacturers must carefully consider the available options because the right connector not only affects the operator’s convenience, but can be the deciding factor in maintaining process sterility and product quality...

Citation:
Boehm J. Connection Technology Advances Closed System Processing: Single-Use Connectors Create Improved Flexibility and Reliability, and Drive Cost Savings for Biopharmaceutical Manufacturers. BioProcess J, 2014; 13(1): 50-55. http://dx.doi.org/10.12665/J131.Boehm.

Posted online April 23, 2014.